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larotrectinib will raise the level or influence of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unfamiliar.Ferraro et al (1997b) examined the in vivo dopamine and GABA amounts of the nucleus accumbens in rats given modafinil, and they uncovered that modafinil experienced an incredibly minor effect o